Digene antacid liquid
Digene Gel is presented as a pleasantly flavored viscous suspension in three delicious flavors: mint, orange and mixed fruit.
May be taken with or without food.
Hypersensitivity to aluminium salts.
Constipation; intestinal obstruction (with large doses); phosphate depletion may occur with prolonged admin or large doses.
Enhanced absorption with citrates or ascorbic acid. Decreases absorption of allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, Fe salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine.
Food decreases gastric emptying time.
MECHANISM OF ACTION
Alumunium hydroxide acts on the HCl in the stomach by neutralization, forming aluminium chloride salt and water.
- Absorption: Alumunium hydroxide reacts with hydrochloric acid in the stomach to form soluble aluminium chloride, which is absorbed from the GI tract.
- Excretion: Absorbed aluminium is excreted via the urine. Insoluble aluminium salts formed in the intestines, eg, hydroxides, carbonates, phosphates and fatty acid derivatives, are excreted in the faeces.
Chronic renal impairment; CHF; oedema; cirrhosis and low Na diets; patients with recent GI haemorrhage. Administer 2-3 hrs before/after another medication to minimise drug interactions. Pregnancy and lactation.